eating a mushroom
eating a mushroom

Forget Highest THC Levels, What are the 5 Most Potent Psychedelics Out There?

Will psychedelics see a consumer trend to most potent items like cannabis has seen in THC levels?

Posted by:
HighChi on Friday Feb 10, 2023

strongest psychedelics

Psychedelic substances can profoundly alter our perception of reality, revealing new dimensions and possibilities. With their vast potential, we are just beginning to tap into their full potential. Although the strength of psychedelics is challenging to quantify, their potency cannot be denied. From natural psychedelics to laboratory-created compounds, these drugs can trigger mystical experiences, transporting users to otherworldly realms.


As the effects of psychedelics vary significantly from person to person, it is challenging to determine which is the strongest. However, a few drugs are known for their particularly intense effects. Here are what could be considered the top five most potent psychedelics.



DMT is a powerful substance with two variations: N, N-Dimethyltryptamine, and 5-MEO-Dimethyltryptamine.

The first form, N, N-Dimethyltryptamine, is the more commonly encountered molecule and can be found in many living organisms. This type of DMT is found in Ayahuasca brews and in its powdered form, which can be smoked or vaped.


On the other hand, 5-MEO-Dimethyltryptamine, with a 5-MEO molecular tail, is less commonly found in nature and less accessible as a drug. This form is found in the venom of a specific toad consumed in some shamanic rituals. Additionally, it can be delivered through the nasal passages using "Yopo." In modern times, it has been paired with ibogaine to explore its potential in addressing addiction.


Despite their different origins, both forms of DMT are known for their incredible potency and intense effects.


Effects of DMT

Both N, N-Dimethyltryptamine, and 5-MEO-Dimethyltryptamine are among the most potent drug experiences one can have. If not the strongest, they are certainly in the running for the title.


N, N-Dimethyltryptamine is a powerful hallucinogen that elicits varying effects depending on the dosage. At lower doses, it can induce intense visual hallucinations, both with eyes closed and open. At higher doses, it can transport users to entirely new realms, where they may encounter otherworldly beings of a mystical nature.


5-MEO-DMT, on the other hand, elicits a strange shift in perspective that is often described as a near-death experience. Being less well-known and less commonly encountered, it remains a largely mysterious substance with obscure, hard-to-define effects. Regardless, its potency cannot be disputed.



Mescaline is a potent psychedelic alkaloid most frequently discovered in certain species of cacti, such as Peyote and San Pedro. With a rich history of shamanic use stretching back centuries, this hallucinogenic compound has captivated the imaginations of people across the world. Its fame reached new heights with the publication of "The Teachings of Don Juan," a book that chronicled the journey of an anthropologist who ventured to Mexico to explore the use of Peyote with a shaman. This fascinating tale introduced Mescaline and its powerful effects to a broader audience, solidifying its place in the annals of psychedelic history.


Effects of Mescaline

Mescaline is said to produce effects that are similar to those of psilocybin, although this comparison is likely a pale one. The effects of Mescaline can be profound and include significant mental, visual, and auditory distortions, including closed and open-eye visuals. Some users report a greater detachment between mind and body, but this is not necessarily experienced as a negative. Wide open spaces enhance the Mescaline experience, while enclosed spaces and forests may feel constricting.


As with all psychedelics, Mescaline provides a deep, reflective, and philosophical experience. However, thoughts and emotions may come and go more quickly with Mescaline than with other psychedelics such as LSD. This makes Mescaline a valuable tool for exploring the self and contemplating big questions. In some cases, total ego death is possible with Mescaline use.



MDMA, commonly known as the party drug, is a unique substance that defies categorization. While it may not strictly be classified as a psychedelic or hallucinogen, its effects are undeniably trippy. Users often report feeling an intense rush of energy and an overwhelming sense of empathy and connection to others.


Contrary to its ancient counterparts, MDMA is a relatively new drug, with its origins dating back just over a century. Developed by the pharmaceutical company Merck in 1912, it was initially used for therapeutic purposes but was soon embraced by the recreational scene in the 1960s and 1970s.


However, with the increasing stigma and outlawing of psychedelics during that time, MDMA faced the same fate and was banned along with other drugs in the same category. Despite this, it remains a popular substance and continues to evoke strong emotions and trippy experiences for those who use it.


Effects of MDMA

MDMA is a powerful and complex drug that induces feelings of happiness, empathy, and love, making it popular in social settings. However, high doses can cause intense hallucinations and physical effects such as elevated heart rate and blood pressure, jaw clenching, and body temperature, making it dangerous if taken in excess or with other drugs.


Despite its euphoric effects, it also has a brutal come-down, leading to physical exhaustion and emotional turmoil. These side effects are usually minimal when taken occasionally and in moderation.



LSD, the mind-bending compound more commonly known as "acid," is a psychedelic of legendary proportions. With just 25 micrograms, you'll be launched into a world of intense, vivid hallucinations and mind-bending experiences. One microgram is a millionth of a gram, making LSD one of the most potent drugs on the planet.

Typically consumed in tab form, the liquid LSD is placed under the tongue, absorbed through the mucous membrane, and into the bloodstream. Alternatively, it can be directly dropped onto the tongue.


Albert Hoffman created this mind-altering substance in 1938 and went on to be the subject of military research exploring its potential to enhance soldiers' abilities. However, these trials proved to be unsuccessful, and LSD instead became synonymous with the hippie movement and a symbol of countercultural expression.


Effects of LSD

LSD is a potent psychedelic known for its fear-inducing and misunderstood reputation. However, it can also lead to enjoyable experiences if approached with caution. LSD can cause powerful changes in perception, vision, and sound, along with altered thoughts that can lead to deep philosophical conversations. Despite its association with the "bad trip" and the hippy movement, LSD remains one of the most potent drugs in the world.



Salvia divinorum, also known as the "Seer's Sage," may be legal in some areas, but it is by no means a mild or inconsequential substance. It is incredibly potent, particularly in extract form, which can be a hundred times stronger than the naturally grown leaf.


While some might try it out of curiosity as teenagers, it is not uncommon for people to never revisit this drug after their initial experience. This has less to do with its quality and more with the assumption that its legality equates to a lack of potency. Salvia divinorum is anything but mild.


Effects of Salvia

Salvia's effects are akin to those of DMT but with a potent rush that can make you feel hurtling through space, even when you're stationary. With its intense visuals and otherworldly experiences, it's essential to proceed cautiously when trying salvia for the first time. Always start with a low dose to get a better handle on the power of this mind-bending substance. Don't be fooled by its legal status - salvia is a severe drug and not to be taken lightly.



Psychedelics are potent substances that can have both profound and potentially dangerous effects. From LSD to MDMA, salvia, and more, it's crucial to approach these drugs with caution and understanding and to understand both the positive and negative consequences that can come with their use.


Whether for personal exploration or social situations, it's essential to respect these substances' power and use them responsibly. With this understanding in mind, the world of psychedelics can offer an incredible journey of self-discovery and growth.





What did you think?

ganja leaf left  Keep reading... click here  ganja leaft right

Please log-in or register to post a comment.

Leave a Comment: